Resource overview

Evidence-to-action resource for neurodegeneration

The NeuroMisfoldome Atlas organizes misfolding-relevant proteins by evidence architecture, comparative state, and experimental priority. This browser provides transparent access to the current versioned release while preserving the underlying audited record.

Search Atlas Compare proteins Download release View data dictionary Read documentation

34 Proteins

3 Atlas states

3 Recommended actions

25 Browser fields

Release landscape

Atlas composition

Counts are generated directly from the browser-facing release table.

Atlas states

Recommended actions

Disease classes

Interpretation guide

Atlas states and recommended actions

Atlas states summarize the current evidence architecture. Recommended actions identify the next resource-building priority and do not constitute clinical or pathogenicity classifications.

State A

Discovery-first

Proteins for which stronger comparative, mechanistic, or annotation support is needed before systematic assay expansion.

Typical action

Discovery-focused follow-up

State B

Assay-build

Proteins with sufficient biological rationale or interpretive priority for assay development, but limited current functional coverage.

Typical action

Build assay coverage

State C

Reference-linked

Proteins with comparatively mature evidence architectures and smaller immediate assay gaps, suited to monitoring and iterative updating.

Typical action

Monitor and update

Search Atlas

Atlas table

Showing 34 of 34 proteins

Search covers all 25 browser-facing fields, including fields not displayed as visible table columns. Click a row, or focus it and press Enter, to open the protein-level summary. The filtered download retains all 25 fields.

Gene	Full protein name	Disease class	Cohort status	Atlas state	Recommended action	Priority rank	Readiness	Opportunity	Evidence completeness	Assay support	Assay gap	Misfolding-feature burden	Expert consensus action	Atlas-expert match

Protein-level view

Gene card

Open a gene from the Atlas table to view its summary, evidence profile, action context, human neural-expression context, and external resource links.

Comparative view

Compare proteins

Select two or three proteins to compare their Atlas states, recommended actions, evidence architecture, uncertainty, misfolding-feature annotations, and expert consensus.

Protein 1 Protein 2 Protein 3, optional

Show only differing fields

Select at least two different proteins.

The comparison matrix and evidence profiles will appear here.

Release and provenance

Resource record

Suggested citation

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Download Atlas release

Release files

The NeuroMisfoldome Atlas is provided as a versioned downloadable resource, with this browser serving as the companion interface for interactive exploration. Available files can be downloaded directly below; the formal archival package and persistent accession will be linked when the release record is finalized.

Download full NeuroMisfoldome Atlas package Available after formal package assembly and archive deposition Download release table Formal versioned release table Download browser table Complete browser-facing table with 25 fields Download refined misfolding-feature annotation table Phase 11 refined annotation layer Download expert adjudication benchmark Structured Atlas-versus-expert comparison Download data dictionary Definitions and source provenance for browser fields Download human neural-expression source data GTEx regional, Allen cell-class, integrated neural-context and disease-relevant neuronal source data with provenance Download figure source data Available after Level 1 package assembly Download analysis code Available after Level 1 package assembly

Documentation

Using the browser

Search and filter

Locate genes or proteins and subset the release by disease class, Atlas state, recommended action, or cohort status.

Inspect evidence architecture

Open a gene card to review its state, action, priority, evidence profile, uncertainty category, expert consensus, misfolding-feature annotations, and independent human neural-expression context.

Compare and share

Compare two or three proteins side by side, download the complete comparison data, or copy a URL that reopens the selected protein or comparison.

Download reproducible data

Download the full browser table or export all 25 fields for the currently filtered set of proteins.

Interpretation note. The Atlas prioritizes evidence architecture and experimental actionability. It is not a pathogenicity classifier, diagnostic tool, or substitute for clinical variant interpretation.